ABSTRACT
Objective To investigate the expression of p38 MAPK gene and p38 MAPK protein,and explore the effect of p38 MAPK in inflammation reaction of severe acute pancreatitis.Methods 48 cases with severe acute pancreatitis were chosen as research group,and another 48 healthy cases as control group.The expression of p38 MAPK gene were investigated by RT-PCR,and the expression of p38 MAPK and P-p38 MAPK protein were investigated by western blot. Results The expression of p38 MAPK mRNA,p38 MAPK protein and P-p38 MAPK protein in research group were higher than that in control group,the differences were all statistically significant(P<0.05 ).Conclusion The expression of p38 MAPK gene and p38 MAPK protein were significantly increased in patients with severe acute pancreatitis,which showed that p38 MAPK played an important role in inflammation reaction.
ABSTRACT
@#ObjectiveTo investigate the relation between morning blood pressure surge(MBPS) and myocardial ischemia.Methods315 patients with primary hypertension and coronary heart disease were received Holter and non-invasive ambulatory blood pressure monitoring(ABPM). According to the morning blood pressure raised, they were divided into MBPS group and no-MBPS group. Then the ABPM and Holter data were compared.ResultsThe patients in MBPS group were older. The myocardial ischemia events were more common in MBPS group than in no-MBPS group. The logistic regress showed that the MBPS was related to myocardial ischemia events even after corrected by age, smoke, and sex.ConclusionMBPS is a risk factor of myocardial ischemia.